What is protein powder?
Protein is the body's basic building material for muscle, skin, hair, nails and immune cells. The amino acids in protein (the small pieces protein is made of) are also used to heal wounds and to make the hormone that helps you sleep (melatonin) and the chemicals that regulate mood.
Protein powder is simply protein made easy to take as a powder or drink. The most common types are whey protein, made from milk, and plant proteins from soy or peas.
Signs of low protein: who needs it
The more of these that apply to you, the more likely you're low on protein.
- □ Your nails break easily, and your hair is dry or falling out a lot
- □ The skin on your fingertips often peels
- □ You eat poorly or are dieting, and you often feel puffy or swollen
- □ You're losing muscle, feel tired, and fall easily
- □ You catch colds easily and cuts are slow to heal
- □ You're often hungry and gain weight easily
These groups in particular have a hard time getting enough from food alone:
- Adults over 50: After age 30, you lose 3–8% of your muscle every 10 years. As you age, less of the protein you eat goes to muscle, so you need more. One survey found that about 2 in 3 people aged 65 and older don't get enough protein.
- People who eat only two meals a day: Most fall short.
- People who are dieting: When you eat less, you lose muscle along with fat.
- Older adults who have trouble chewing or digesting: It's hard for them to eat enough meat.
- Women in menopause: Losing muscle raises the risk of falls and broken bones.
On Wegovy or Mounjaro? Start with protein
GLP-1 appetite-suppressing shots (Wegovy, Mounjaro and others) make you eat much less. When that happens, you lose muscle along with fat.
In one large study, people who lost about 20% of their body weight also lost about 11% of their lean mass (body weight minus fat), which includes muscle.
That's why, if you're on one of these shots, strength training plus extra protein is considered the top priority. Many people also add creatine to help prevent muscle loss.
How much protein do you need per day?
Bottom line: about 1 g per kg of body weight (about 0.45 g per lb). More if you're older or active.
| Situation | Total daily protein (food + powder) | For 60 kg (132 lb) |
|---|---|---|
| Healthy adult, maintenance | 0.8–1 g per kg of body weight | About 48–60 g |
| Over 50, or worried about muscle loss | 1–1.3 g per kg of body weight | About 60–80 g |
| Doing strength training | About 1.5 g per kg of body weight | About 90 g |
Of this, use powder only for the gap — usually about half of what you need, or 20–30 g. A product with at least 10–15 g per serving, taken 1–2 times a day, will get you there.
- Don't take too much at once. A large amount at one time puts strain on your liver, kidneys and stomach. Older adults in particular find it hard to take 30–40 g at once.
- Be careful above 1.5 g per kg. Some experts suggest up to 1.5–2 g while on weight-loss medication, but some data show that more than 1.5 g per kg can strain the kidneys.
- Extreme amounts are dangerous. Getting more than 35% of your daily calories (about 200 g) from protein over a long time can cause "protein poisoning." Ammonia builds up in the blood, the liver and kidneys are damaged, and you get diarrhea.
When to take protein powder: before or after a workout?
Bottom line: how much you get in a day matters far more than when you take it.
The idea that you have to drink protein within 30 minutes after a workout to build muscle used to be popular, but it's been disproven. An analysis that pooled 23 studies found that total amount mattered more than timing, and other research found no difference between taking it before or after exercise.
- If you work out, take it within 2 hours afterward so you don't forget.
- If you don't work out, the morning is a good time. You stay full longer and your blood sugar rises more slowly.
- Split it into 2 servings a day. 3–4 is ideal, but realistically 2 (morning and evening) is enough.
- If it upsets your stomach, take it after a meal. You can take it on an empty stomach or as a meal replacement, but after a meal is easier if your stomach is sensitive.
- Take it at a different time from amino acid supplements like collagen or arginine. They compete for absorption.
Types of protein powder: WPC vs WPI vs WPH vs plant
If you're new, whey protein isolate (WPI) is the safest pick. If dairy doesn't agree with you, go plant-based. The type makes almost no difference in how well it builds muscle.
| Type | What it's like | Best for |
|---|---|---|
| Whey concentrate (WPC) | Cheaper, but has more lactose (milk sugar). | Younger people with no digestion issues |
| Whey isolate (WPI) | About 90% pure protein, low in lactose. Absorbed quickly and tastes fine. Best value overall. | Most people, after workouts |
| Hydrolyzed whey (WPH) | Pre-broken into small pieces, so it's the easiest to digest. But it costs almost twice as much. | People with a weak stomach or trouble digesting |
| Casein | The slow-absorbing part of milk protein. Keeps you full longer. | People struggling with hunger while dieting |
| Pea protein | Less likely to cause allergies, easy to digest. | People who don't do well with dairy, women, older parents |
| Organic plant blend | A mix of grains, seeds and nuts, with some minerals and fiber. Pricey, and people either like the taste or don't. | People who eat few vegetables, people losing hair from constipation or poor nutrition |
| Essential amino acid capsules | Just the essential building blocks of protein in pill form. | People who don't want to scoop powder |
Experts disagree on whether plant or whey protein is easier on the liver and kidneys. Some say high-purity whey is actually less of a burden; others say plant protein is better because it avoids lactose and allergy issues. To keep it simple: worried about your liver or kidneys? High-purity WPI. Dairy doesn't agree with you? Plant protein.
Powder vs. ready-to-drink: If your goal is protein, powder wins on both protein content and value. Drinks are convenient, but many are "complete nutrition" shakes that are more about vitamins and minerals than protein, so always check the grams of protein.
How to choose a protein powder: 4 things to check on the label
- Grams of protein per scoop — For example, 27 g of protein in a 31 g scoop. The higher the protein compared with the scoop weight, the purer it is.
- Sugar, carbs and sodium — Less is better. Even with "0 g sugar," many products are sweetened with artificial sweeteners like sucralose.
- Contamination testing — Choose brands that publish results for bacteria, mold and heavy metal testing.
- Certifications for plant protein — Look for USDA Organic, vegan and Non-GMO seals. Some "plant" products are actually mixed with whey.
Also keep in mind:
- Taste comes first. You'll drink it every day, so you need to like it to stick with it. Buy a small tub first.
- Avoid sports products that promise "bulking" or "testosterone boosting." Some have been found to contain illegal drugs and raised liver enzymes.
- If your kidneys aren't healthy, check whether minerals like calcium, magnesium or potassium have been added. On the other hand, if your kidneys are healthy, a product with calcium and magnesium can double as bone support.
Protein powder side effects: kidneys, liver, acne
If you're healthy and stick to the recommended amount, you're fine. Studies found that a moderate amount of protein powder didn't affect the liver. Problems come up when you take a lot, or when your liver or kidneys already aren't healthy.
- Kidney strain and stones: Extra protein breaks down into waste like urea and uric acid, and your blood tips toward acidic, which makes stones more likely.
- Dehydration: You urinate more. Drink more water than usual.
- Liver strain: Processing protein creates ammonia, which the liver filters out. In people with serious liver disease, this can lead to hepatic encephalopathy (confusion caused by ammonia buildup).
- Digestive upset: Concentrated protein can easily upset the stomach in older adults or people with gastritis or bowel conditions. Split your servings, take it after meals, or switch to WPH or plant protein.
- Acne: Whey protein is a well-known acne trigger. If your acne gets worse, switch to plant protein.
Talk to your doctor before taking it if any of these apply:
- You have poor kidney function, take kidney medication, or have heart failure
- You have reduced liver function or liver disease
- You often get kidney or urinary stones (if you take it, stick to a moderate amount)
- You have gout
- You have a stomach condition like gastritis or a stomach ulcer
For reference, calorie for calorie, protein is less likely to turn into body fat than carbs. That's why a protein shake is a better snack choice when you're dieting.
Medications and conditions to watch
- Caution Kidney disease, kidney medications, heart failure — Strains the kidneys, which filter protein waste — talk to your doctor before taking
- Caution Liver disease — Strains ammonia processing; in severe cases, risk of hepatic encephalopathy — talk to your doctor
- Check Gout — Byproducts like uric acid may rise — moderate amounts only, and talk to your doctor
- Check Kidney or urinary stones — May make stones more likely — moderate amounts only, and drink plenty of water
- Note Collagen — Amino acids compete for absorption — take at different times if you can
- Note L-Arginine — Amino acids compete for absorption — take at different times if you can
Combinations
Works well with: Creatine, Essential amino acids (EAA)
Space apart from: Collagen, L-Arginine
How it appears on the label
| On the label | What it is | What it means |
|---|---|---|
| Whey Protein Isolate | Whey protein isolate (WPI) | More lactose and fat filtered out, so higher in protein. Choose this if you're sensitive to lactose |
| Whey Protein Concentrate | Whey protein concentrate (WPC) | Lower cost and contains a little lactose |
| Hydrolyzed Whey | Hydrolyzed whey | Whey broken into small pieces. Expensive |
| Pea Protein Brown Rice Protein | Plant protein (pea, brown rice) | For vegans. Mixing the two fills in each other's amino acids |
| Casein Micellar Casein | Casein | Slow-absorbing milk protein |
Best Protein powder supplements on Amazon, compared
Bottom line
We checked the labels of 14 popular protein powder products on Amazon: 4 recommended, 10 depend on your needs, 0 not recommended.
- Best overall — Dymatize ISO100 Hydrolyzed 100% Whey Protein Isolate, Gourmet Vanilla (20 servings): High-purity whey made only from hydrolyzed isolate and isolate (Per serving: 1 scoop (30 g): protein 25 g)
- Sport certified — Optimum Nutrition Gold Standard 100% Whey, Double Rich Chocolate, 2 lb: Mainly whey isolate, with some concentrate (includes lactase, the lactose-digesting enzyme) (Per serving: 1 scoop (30.4 g): protein 24 g)
- Simple ingredients — Isopure Isopure Zero Carb Whey Isolate Protein Powder, Unflavored 1 lb: Unflavored powder with just whey isolate and soy lecithin — no sweeteners or flavors (Per serving: 1 scoop (29 g): protein 25 g)
- Vegan — NAKED Nutrition NAKED Pea, 100% Pea Protein, Unflavored 5 lb (76 servings): Per seller: yellow pea protein only, no sweeteners or flavors (Per serving: Protein 27 g per serving (per seller))
Recommended 4
ISO100 Hydrolyzed 100% Whey Protein Isolate, Gourmet Vanilla (20 servings)
Hydrolyzed whey isolate + whey isolate (WPI) powder, vanilla · Per serving: 1 scoop (30 g): protein 25 g · Cost per day: average
- High-purity whey made only from hydrolyzed isolate and isolate
- 25 g protein per scoop, 110 calories — about 23 g per 100 calories
- 0 g added sugar (sweetened with sucralose and stevia)
- Informed Choice banned-substance testing seal on the label
- Lowest cost per 25 g protein among the verified whey products
First-time buyers, people slightly sensitive to dairy or with weak digestion, post-workout
View on Amazon Find on iHerbGold Standard 100% Whey, Double Rich Chocolate, 2 lb
Mostly whey isolate (WPI) + concentrate and whey peptides powder, chocolate · Per serving: 1 scoop (30.4 g): protein 24 g · Cost per day: average
- Mainly whey isolate, with some concentrate (includes lactase, the lactose-digesting enzyme)
- 24 g protein per scoop, 120 calories — 20 g per 100 calories
- 1 g sugar (sweetened with acesulfame potassium)
- Informed Choice banned-substance testing seal on the label
- Average cost per 25 g protein
People who want a basic whey that tastes and mixes well (if you're very sensitive to dairy, pure WPI is easier)
View on Amazon Find on iHerbIsopure Zero Carb Whey Isolate Protein Powder, Unflavored 1 lb
Unflavored whey isolate (WPI) powder · Per serving: 1 scoop (29 g): protein 25 g · Cost per day: high
- Unflavored powder with just whey isolate and soy lecithin — no sweeteners or flavors
- 25 g protein per scoop, 100 calories — the highest protein per 100 calories in this comparison
- 0 g carbs and fat
- A bit of sodium at 230 mg per scoop
- Higher cost per 25 g protein
People who don't like sweet, people mixing into coffee, yogurt or cooking, people cutting carbs
View on Amazon Find on iHerbIsopure Clear Whey Isolate Protein Powder, Citrus Lemonade 1.9 lb
Clear whey isolate (WPI) drink powder, lemonade · Per serving: 1 scoop (25 g): protein 20 g · Cost per day: high
- Just 5 ingredients: whey isolate, natural flavor, citric acid, stevia, turmeric (color)
- Not a milky shake — mixed with water it's clear like juice
- 20 g protein per scoop, 90 calories — about 22 g per 100 calories, no artificial sweeteners
- Higher cost per 25 g protein
People tired of milky shakes, people who want something light during workouts or on hot days
View on Amazon Find on iHerbDepends on your needs 10
Premier Protein 30g Protein Powder, 100% Whey, Chocolate, 17 servings
Whey isolate + concentrate powder, chocolate · Per serving: 1 scoop: protein 30 g (per seller) · Cost per day: low
- Per seller: whey isolate and concentrate, 30 g protein per scoop, 150 calories, 1 g sugar
- 30 g at once — older adults or people with sensitive stomachs should split into half scoops
- Sweetened with sucralose and acesulfame potassium
- Not verified in the label database (NIH)
People who want a lot of protein in one serving (check the label when it arrives)
View on Amazon Find on iHerbNAKED Whey, Grass Fed Whey Protein, Unflavored 1 lb (15 servings)
Whey concentrate (WPC) only, unflavored powder · Per serving: Protein 25 g per serving (per seller) · Cost per day: high
- Per seller: whey concentrate only, no sweeteners or flavors
- 25 g protein per serving, 120 calories (about 21 g per 100 calories)
- Concentrate, so a bit more lactose than isolate
- NSF certified per seller; not verified in the label database (NIH)
- Higher cost per 25 g protein
People who want additive-free whey and aren't sensitive to dairy
View on Amazon Find on iHerbNAKED Pea, 100% Pea Protein, Unflavored 5 lb (76 servings)
Pea protein only, unflavored powder · Per serving: Protein 27 g per serving (per seller) · Cost per day: low
- Per seller: yellow pea protein only, no sweeteners or flavors
- 27 g protein per serving, 120 calories — about 22 g per 100 calories, the highest among plant proteins
- Dairy-free, so it works for people who don't do well with milk
- Lowest cost per 25 g protein in this comparison
- NSF certified per seller; not verified in the label database (NIH)
People who don't do well with dairy, people worried about acne, people who want a big tub that lasts (bland taste — blend with fruit)
View on Amazon Find on iHerbRaw Organic Protein, Vegan, Vanilla, 20 servings
Organic pea, sprouted grain and seed plant protein powder, vanilla · Per serving: 1 scoop: protein 22 g (per seller) · Cost per day: low
- Per seller: organic pea, sprouted grain and seed protein, 22 g per scoop, 130 calories, 0 g sugar
- Also has digestive enzymes, probiotics and 5 g fiber
- USDA Organic and vegan certified (per seller)
- Current label not verified in the label database (NIH)
People who don't do well with dairy, people who want organic plant protein (taste is hit or miss — start with a small tub)
View on Amazon Find on iHerbRaw Organic Meal Shake & Meal Replacement, Vanilla, 28 servings
Organic plant-based meal replacement powder (with vitamins and minerals), vanilla · Per serving: 1 scoop (37.5 g): protein 20 g (per seller) · Cost per day: average
- Per seller: 20 g protein per scoop, 150 calories, 13 g carbs, 7 g fiber, 0 g sugar
- Meal-replacement style with vitamins and minerals — check for overlap with your multivitamin
- About 13 g protein per 100 calories, less efficient if you just want protein
- Not verified in the label database (NIH)
People who often skip breakfast and want to replace one meal a day (don't replace every meal)
View on Amazon Find on iHerbOrganic Vegan 21g Protein Powder, Creamy Chocolate Fudge, 2.03 lb
Organic pea, brown rice, mung bean and chia plant protein powder, chocolate · Per serving: 2 scoops: protein 21 g (per seller) · Cost per day: average
- Per seller: organic pea, brown rice, mung bean and chia, 21 g protein in 2 scoops, 150 calories, 0 g sugar
- Contains a sunflower oil and rice dextrin creamer, so about 14 g protein per 100 calories
- Sweetened with stevia, contains fiber
- Not verified in the label database (NIH)
People who don't do well with dairy and want a smooth-tasting plant protein
View on Amazon Find on iHerbOrganic Vegan 21g Protein + 50 Superfoods Powder, Vanilla Bean, 2.02 lb
Organic pea, brown rice and chia protein + vegetable and fruit powder blend, vanilla · Per serving: 2 scoops: protein 21 g (per seller) · Cost per day: low
- Per seller: 21 g protein in 2 scoops, 160 calories, 1 g sugar, 8 g fiber
- Doesn't say how much of each of the 50 superfoods it contains (total protein is listed)
- About 13 g protein per 100 calories, so protein efficiency is low
- Not verified in the label database (NIH)
People who eat few vegetables and want fiber too
View on Amazon Find on iHerbPurely Inspired Organic Plant-Based Protein Powder, Creamy French Vanilla (16 servings)
Organic pea and brown rice protein powder, vanilla · Per serving: 1 scoop: protein 20 g (per seller) · Cost per day: low
- Per seller: organic pea and brown rice protein, 20 g per scoop, 4 g fiber
- Ingredients include a little organic cane sugar
- The NIH label database only has an older label (22 g per scoop), so we couldn't match it to the current product
- Lower cost per 25 g protein
People who want to try plant protein on a budget (check sugar on the label when it arrives)
View on Amazon Find on iHerbCore Power 26g Protein Milk Shake, Ready To Drink, Chocolate, 14 fl oz x 12
Ready-to-drink shake, ultra-filtered milk protein, chocolate · Per serving: 1 bottle (414 mL): protein 26 g (per seller) · Cost per day: high
- Per seller: made from ultra-filtered milk, 26 g protein per bottle, with lactase (lactose-digesting enzyme) added
- Sweetened with sucralose, acesulfame potassium and more; contains carrageenan
- Highest cost per 25 g protein in this comparison (about 2x powders)
- A beverage, so not verified in the label database (NIH)
People who find mixing powder a hassle, when you need something to drink right after a workout
View on Amazon Find on iHerbSYNTHA-6 Protein Powder, 5 lb (48 servings)
Whey, casein and milk protein blend + creamer powder · Per serving: 1 scoop: protein 22 g (per seller) · Cost per day: average
- Blend of 6 proteins (22 g total is listed, but not the ratio of each) — the casein keeps you full longer
- Per the older label, about 200 calories per scoop, so about 11 g protein per 100 calories — lots of creamer (sunflower oil, corn syrup solids) and maltodextrin
- Sweetened with sucralose and acesulfame potassium
- The NIH label database only has an older label, so we couldn't match it to the current product
People who care most about taste or need extra calories (if you're trying to lose weight, whey isolate is a better fit)
View on Amazon Find on iHerbFrequently asked questions
How much protein should I eat per day?
About 1 g per kg of body weight is the standard. If you weigh 60 kg (132 lb), that's about 60 g a day. If you're over 50 or do strength training, you can go up to 1.3–1.5 g per kg.
Should I take protein powder before or after a workout?
Many studies show little difference. Your daily total matters more than timing, so taking it within 2 hours after your workout, so you don't forget, is plenty.
Can I take protein powder if I don't work out?
Yes, if you're not getting enough protein from food. It may help protect muscle, especially if you're over 50 or dieting. Taking it in the morning also keeps you full longer.
Is protein powder bad for your kidneys?
If your kidneys are healthy and you take a moderate amount, it's fine. But going over 1.5 g per kg of body weight, or having kidney problems already, can be a strain — talk to your doctor. Drink plenty of water too.
What's the difference between WPI and WPC?
WPI (whey isolate) is about 90% pure protein and low in lactose. WPC (whey concentrate) is cheaper but has more lactose, so it may upset your stomach if you're sensitive to dairy.
Does plant protein build muscle too?
Most experts say it builds muscle about as well as whey. If dairy doesn't agree with you or you're worried about allergies, choose pea or organic plant protein.
Can I replace meals with protein shakes?
About one meal a day is fine. But replacing every meal leaves you short on vitamins and minerals.
I broke out after starting protein powder.
Whey protein is a common acne trigger. Try switching to plant protein.
Related concerns
Last updated 2026-10-12